منابع مشابه
Engineering Signal Transduction Pathways
Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryotic systems to create new functionalities and for specific applications. In this review, we discuss the challenges associated with engineering signal transduction pathways. Furthermore, we address advant...
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This thesis presents mathematical and computational approaches to studying signal transduction pathways. The biology of cellular signalling is introduced, highlighting the importance of signalling pathways in regulating the processes of cell division and proliferation. A brief history of mathematical approaches to such systems is presented. Two multivariate analysis methods, principal component...
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متن کاملSimulation of signal transduction pathways
Signal transduction is about how molecular mechanisms in cells are used to receive, process and respond to signals from outside and inside of the cell. The term signal is defined in a dual way in this context: being the molecular state of a molecule, e.g. a protein, and at the same time an abstract logical state (active/inactive). This thesis focuses on intracellular signalling: i.e. receiving ...
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ژورنال
عنوان ژورنال: Cell
سال: 2010
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.12.028